Table 2 Brain areas showing significant changes in activation after duloxetine treatment in oxaliplatin-treated macaques.

From: Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity

Area

Hemisphere

Z value

x

y

z (mm)

After duloxetine treatment (Post-oxaliplatin, 10 °C–37 °C) > Intact (10 °C–37 °C)

Cb

Left

3.63

8

−12

−6

V1

Left

3.43

−10

24

2

TFO

Left

3.12

8

−2

−6

Before > After duloxetine treatment (Post-oxaliplatin, 10 °C–37 °C)

STG

Left

3.89

20

20

−10

MI

Right

3.49

−8

4

20

SII/Ins

Right

3.35

−16

22

2

Cb

Left

2.93

6

−8

−12

  1. Z -value of the peak voxels are indicated. The locations are indicated with the positions along the x (ipsi-contralateral), y (rostro-caudal) and z (dorso-ventral) axes of the Horsley-Clarke stereotaxic coordinates. Cb, cerebellum; Ins, Insular cortex; MI, primary motor cortex; SII, secondary somatosensory cortex; STG, superior temporal gyrus; TFO, area TFO of the parahippocampal cortex; V1, primary visual cortex.
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