Figure 2 | Scientific Reports

Figure 2

From: Homer binds to Orai1 and TRPC channels in the neointima and regulates vascular smooth muscle cell migration and proliferation

Figure 2

Increased protein expression and interaction of TRPC channels and Orai1 with Homer1 in neointima from balloon-injured rat carotid artery. Protein expression levels of Homer1 along with TRPC1, TRPC3, TRPC4, TRPC6, and Orai1 (a–f) are upregulated in injured (media + neointima) compared to uninjured VSMCs. Co-immunoprecipitation assay using anti-Homer1 antibody to immunoprecipitate Homer1 shows that Homer1 interacts with (a) TRPC1; (b) TRPC3; (c) TRPC4; (d) TRPC6; and (e) Orai1 in injured VSMCs. (g) Summary of protein expression normalized to β-actin in uninjured (U) and injured (I) VSMCs (n = 4). *p < 0.05 or better compared to uninjured VSMCs.

Back to article page