Figure 6
In vivo effect of the FID deletion in ElrA in two mice infection models. (A) Groups of 15 BALB/c mice were challenged transurethrally with the OG1RF wild-type, VE14201 ΔelrA, VE18355–3 and VE18355–4 elrAΔFID strains. Data are expressed as the log10 colony-forming units (CFUs) recovered per gram of kidneys or urinary bladder homogenates collected 48 hours after the challenge. The log10 CFUs from both kidneys were combined and averaged. A value of 0 was assigned to the uninfected organs. Horizontal bars represent the geometric means. P values of less than 0.05 were considered to be significant. (B) Groups of 10 BALB/c mice were contrast to the ElrA-deficient strain infected with the OG1RF wild-type, VE14201 ΔelrA, VE18355–3 and VE18355–4 elrAΔFID strains. Data are expressed as the log10 colony-forming units (CFUs) recovered per gram of kidneys or liver homogenates collected 7 days after the challenge. Horizontal bars represent the geometric means. P values of less than 0.05 were considered to be significant.
