Figure 7
From: Genetic and functional characterization of disease associations explains comorbidity
Proposed molecular mechanism underlying Alzheimer’s and neoplasms comorbidity. (A) Diagram of mitochondrial meditated apoptosis and TP53. Representation of the apoptosis pathway. Note that most genes cited in the text are pro-apoptotic molecules. (B) Interaction between the apoptosis regulator BAX and BH3-interacting domain death agonist BID. Cartoon representation of BAX (light blue) and BID (light orange) protein complex. Residues associated with mutations involved in neoplasm are shown in sphere representation in red for BID (L105P, R84W and G94E) and in blue for BAX (G108V). It is worth noting that G108 in BAX faces G94 in BID and that R65L mutation is not detected in the structure of the complex.
