Table 1 Tyrosine kinase substrates on the peptide array and the corresponding kinases.

From: Generation of novel patient-derived CIC- DUX4 sarcoma xenografts and cell lines

Array ID

Sequence

UniProt ID

Position

Kinase

CD79A_181_193

EYEDENLYEGLNL

P11912

Y188

SRC-type Tyr-kinases Lyn

EFS_246_258

GGTDEGIYDVPLL

O43281

Y253

Src

ENOG_37_49

SGASTGIYEALEL

P09104

Y44

—

SRC8_CHICK_476_488

EYEPETVYEVAGA

Q01406

Y483

Src, PTK2

SRC8_CHICK_492_504

YQAEENTYDEYEN

Q01406

Y499

Src

PLCG1_764_776

IGTAEPDYGALYE

P19174

Y775

EGFR, Syk

FRK_380_392

KVDNEDIYESRHE

P42685

Y387

Tyrosine-protein kinase FRK

PAXI_111_123

VGEEEHVYSFPNK

P49023

Y118

PTK6, PTK2

P85A_600_612

NENTEDQYSLVED

P27986

Y607

Src, Insr, PI3K

PAXI_24_36

FLSEETPYSYPTG

P49023

Y31

PTK6, PTK2

PGFRB_572_584

VSSDGHEYIYVDP

P09619

Y581

PDGFRB

CDK2_8_20

EKIGEGTYGVVYK

P24941

Y15

Wee1-like protein kinase

LAT_249_261

EEGAPDYENLQEL

O43561

Y255

—

EPHA2_765_777

EDDPEATYTTSGG

P29317

Y772

—

RET_1022_1034

TPSDSLIYDDGLS

P07949

Y1029

Proto-oncogene tyrosine-protein kinase receptor Ret

PECA1_706_718

KKDTETVYSEVRK

P16284

Y713

Tyrosine-protein kinase Fer

FES_706_718

REEADGVYAASGG

P07332

Y713

Tyrosine-protein kinase Fes/Fps

VGFR2_989_1001

EEAPEDLYKDFLT

P35968

Y996

VEGFR-2

EPHA1_774_786

LDDFDGTYETQGG

P21709

Y781

Ephrin type-A receptor 1

  1. Tyrosine kinases were predicted by screening Phospho.elm (http://phospho.elm.eu.org) and Uniprot (http://www.uniprot.org) databases.