Table 1 Clinical characteristics of study subjects and distribution to training and test set.
From: Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children
Training set | Test set | |||||
|---|---|---|---|---|---|---|
TB disease n = 47 (%) | HHCs n = 36 (%) | p-value | TB disease n = 24 (%) | Non-TB cases n = 26 (%) | p-value | |
Definite = 19 (40) | Definite = 17 (70) | |||||
Probable = 28 (60) | Probable = 7 (30) | |||||
Demographics | ||||||
Age in months (mean) | 108 | 104 | 0.47 | 102 | 19 | <0.0001 |
Range | 9–175 | 12–216 | 24–175 | 2–27 | ||
Gender (male) | 19 (40) | 19 (53) | 0.26 | 11 (46) | 18 (69) | 0.09 |
Mycobacterial exposure | ||||||
Known BCG vaccination | 41 (87) | 28 (78) | 0.25 | 23 (96) | 26 (100) | 0.29 |
Known TB exposure | 16 (34) | 36 (100) | <0.0001 | 8 (33) | 4 (15) | 0.14 |
Tuberculin skin test | ||||||
Positive (≥10 mm) | 44 (94) | 15 (42) | <0.0001 | 24 (100) | 10 (38) | <0.0001 |
Median (mm) | 18 | 15 | 19 | 6 | ||
Quantiferon Gold in tube | ||||||
Positive (≥0,35 IU/mL) | 31 (66) | NA3 | 17 (71) | 9 (35) | 0.01 | |
Indeterminate | 1 (2) | NA3 | 0 | 0 | ||
Median (IU/mL) | 1.6 | NA3 | 1.5 | 0.035 | ||
Symptoms | ||||||
Cough >2 weeks | 28 (60) | 0 | <0.0001 | 16 (67) | 13 (50)4 | 0.23 |
Fever >1 week | 38 (81) | 0 | <0.0001 | 17 (71) | 9 (35)4 | 0.01 |
Weight loss/Failure to thrive1 | 35 (75) | 1 (3) | <0.0001 | 18 (75) | 23 (88) | 0.94 |
Findings | ||||||
Abnormal Chest X-ray | 46(98) | 0 | <0.0001 | 23 (96) | 1 (4) | <0.0001 |
BMI-for-age <−2 Z-Scores2 | 21 (45) | 9 (25) | 0.05 | 14 (58) | 15 (58) | 0.96 |
