Figure 6 | Scientific Reports

Figure 6

From: Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens

Figure 6

Electron density maps and comparison of SSCSSCPLSK, SSCPLSK and SSCSSC + SSCPLSK peptides bound to HLA-A*11:01. Omit maps (F o -F c ) at 2.5 σ in green mesh and 2F o -F c maps at 1 σ in blue mesh after final refinement for each epitope in complex with HLA-A*11:01 (grey) are shown respectively in (a) and (b) for SSCSSCPLSK (green; PDB code: 5GRD); (c) and (d) for SSCPLSK (orange; PDB code: 5GSD); as well as (e) and (f) for SSCSSC + SSCPLSK (dark blue and magenta; PDB code: 5GRG). The peptide residues are represented in sticks. (g) The three peptides in the cleft of HLA*11:01 molecules were overlaid and compared. The left panel shows the top view of three peptides, SSCSSCPLSK (green), SSCPLSK (orange) and SSCSSC + SSCPLSK (dark blue and magenta) bound to HLA-A*11:01 molecule obtained by aligning only the Cα atoms. The right panel shows the side view of the overlap of the three peptides and the α2 domain of HLA-A*11:01 molecule is removed for clarity purpose. N- and C-termini of the peptides are labelled.

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