Figure 2 | Scientific Reports

Figure 2

From: Controllable Microfluidic Production of Drug-Loaded PLGA Nanoparticles Using Partially Water-Miscible Mixed Solvent Microdroplets as a Precursor

Figure 2

(a) Map of flow behavior in the (Qcon, Qdis) plane for fixed V DCM /V DMSO  = 1/10. Optical microscopy images (height: 870 µm) show different forms of the jet. Thin jets broke into tiny droplets at a well-defined location (I, solid squares). Other regimes led to droplets with periodic modulations: droplets with a diameter smaller than twice the nozzle size (II, open circles), and droplets with a diameter larger two times the nozzle size (III, open triangles). Finally, wide straight jets were stable at nozzle, and then diffused within water through the channel (IV, open inverted triangles). (b) Boundaries between droplets and jets shifted as the V DCM /V DMSO was changed. Concentration of PLGA (Mw = 4000~15000 g/mol) = 5 mg/mL, in two DCM/DMSO mixtures (1/10 and 1/20 v/v). The boundaries of the flow diagram depend slightly upon the history of the experiment and upon the experiments. This explains why in some situations, we have reported two symbols for a given experimental condition.

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