Table 1 Hydrodynamic diameter and PDI measured by DLS characterizing the broadness of the size distribution of PLGA NPs collected from the reservoir.

From: Controllable Microfluidic Production of Drug-Loaded PLGA Nanoparticles Using Partially Water-Miscible Mixed Solvent Microdroplets as a Precursor

Region

I: Qdis = 50 µl/hr Qcon = 6000 µl/hr

II: Qdis = 50 µl/hr Qcon = 4000 µl/hr

III:Qdis = 50 µl/hr Qcon = 3000 µl/hr

IV:Qdis = 50 µl/hr Qcon = 1000 µl/hr

Hydrodynamic Diameter (nm)

103

106

128

321

Polydispersity Index

0.03

0.08

0.10

0.27

PDI width (nm)

15

31

41

167

  1. Concentration of PLGA (Mw = 4000~15000 g/mol) = 5 mg/mL in DCM/DMSO mixture, V DCM /V DMSO  = 1/10. The PDI width is the standard deviation of size distribution computed from the square root of the PDI times the average hydrodynamic diameter.
Back to article page