Table 2 Comparison of drug encapsulation efficiency (EE) and loading capability (LC) of PLGA NPs prepared at different flowrate ratios, compositions V DCM /V DMSO , and initial feeding drug concentrations.

From: Controllable Microfluidic Production of Drug-Loaded PLGA Nanoparticles Using Partially Water-Miscible Mixed Solvent Microdroplets as a Precursor

Drug

Drug Feed (mg/mL)

Flow ratio (Qdis/Qcon, µL/hr)

V DCM /V DMSO

EE (%)

Mass Loading Capability LC (%)

Diameter+/−S.D. (nm)

DOX

1

50/10000

0/10

47 ± 2

9.5 ± 0.5

74 ± 9

DOX

1

50/10000

1/20

49 ± 11

10 ± 2

92 ± 4

DOX

1

50/10000

1/10

56 ± 15 (23 ± 0.5)*

11 ± 3 (4.5 ± 0.1)*

106 ± 10 (153 ± 4)*

DOX

1

50/5000

0/10

57 ± 4

11 ± 1

138 ± 5

DOX

1

50/5000

1/20

74 ± 8

15 ± 2

138 ± 3

DOX

1

50/5000

1/10

80 ± 2 (60 ± 3)*

16 ± 0.3 (12 ± 0.5)*

169 ± 2 (202 ± 8)*

DOX

2

50/10000

1/10

51 ± 3

21 ± 1

188 ± 5

DOX

2

50/5000

1/10

65 ± 4

26 ± 2

227 ± 3

TAM

1

50/10000

1/10

88 ± 6

18 ± 1

196 ± 4

TAM

1

50/5000

1/10

77 ± 5

15.5 ± 1

211 ± 5

  1. Concentration of PLGA (Mw = 4000~15000 g/mol) = 5 mg/mL. Asterisk symbol represents data by bulk method with same parameters. (n = 3; mean ± S.D.).
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