Figure 5
Sequential filtering of UPR interactome. (a) Initial UPR network; (b) Network after filtering by differential expression in human HD caudate nucleus samples using the criteria log2 fold change ≥ +0.25 and ≤−0.25; (c) Network of dysregulated components which have been indicated as potential therapeutic targets for HD; (d) Final network obtained after filtering using protein-drug target information (DrugBank). Red and green nodes indicate up and down regulated genes, respectively, and large grey nodes represent query proteins.
