Table 1 Molecular interaction datasets integrated in HDNetDB.

Source	Number of proteins	Number of interactions	Type of interaction	Methods	Reference
HTT-HTP	925	1022	Physical protein interaction	Y2H screens and AP-MS	20, 24,25,26
MDC-Y2H	1713	3340	Physical protein interaction	Y2H screen	55
CCSB	3741	6821	Physical protein interaction	Y2H screen	56
HPRD	12613	65227	Physical protein interaction	Literature curation	57
BioGRID	14822	124035	Physical protein interaction	Literature curation	58
BIND	11524	19352	Physical protein interaction	Literature curation	59
DIP	3025	2925	Physical protein interaction	Literature curation	85
IntAct	13611	37629	Physical protein interaction	Literature curation	86
Reactome	5315	108867	Physical protein interaction	Pathway curation	87
COCIT	3737	6580	Functional association	Text mining	63
ORTHO	6056	62863	Physical protein interaction	Computational prediction	64
HOMOMINT	6221	21863	Physical protein interaction	Computational prediction + Literature curation	88
OPHID	7874	81677	Physical protein interaction	Computational prediction	89
TRANSFAC	742	1554	Regulatory transcriptional interaction (Transcription factor-based)	Literature curation	67
miRTarBase	2234	3565	Regulatory post-transcriptional interaction (microRNAs-based)	Literature curation	90
HTRIdb	1634	2263	Regulatory transcriptional interactions (Transcription factor-based)	Literature curation	69

The source, number of imported proteins and interactions, type of interaction and methodology used for original identification of the interactions as well as the reference are listed.

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