Figure 5 | Scientific Reports

Figure 5

From: Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy

Figure 5

Differentiation model of LepR+Runx2-GFPlow cells into osteoblasts. LepR+Runx2-GFPlow cells form multilayered structures along the bone surface in response to intermittent PTH treatment. In this process, the LepR+Ranx2-GFPlow cells increase the expression levels of Runx2, Osx and Col1 sequentially, and eventually differentiate into mature osteoblasts.

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