Figure 4 | Scientific Reports

Figure 4

From: Free immunoglobulin light chain (FLC) promotes murine colitis and colitis-associated colon carcinogenesis by activating the inflammasome

Figure 4

FLC was evaluated in the AOM/DSS-induced colitis-associated colorectal cancer tissues. Mice were injected i.p. with a single dose (10 mg/kg) of AOM, and then mice were given 3 cycles of 2.5% DSS administered in the drinking water for 7 days, followed by 14 days of regular water. Mice were sacrificed on day 91 after CAC induction. (A) A number of visible tumors on day 91 is shown. Scale bars: 100 μM. (B) Igκ and Igλ in the hydrophobic component of colon tissue were quantified by reduced western blot. (C) Igκ and Igλ in the serum were detected by reduced western blot. (D) The Igκ staining in the colon or tumor tissues was performed with immunohistochemistry. Scale bars: 100 μM. NC: normal control mice, AOM + DSS: AOM/DSS-induced CAC mice. One representative experiment of two is displayed.

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