Figure 6 | Scientific Reports

Figure 6

From: Free immunoglobulin light chain (FLC) promotes murine colitis and colitis-associated colon carcinogenesis by activating the inflammasome

Figure 6

F991 inhibited inflammasome activation and inflammatory cell infiltration in the AOM/DSS-induced CAC model. (A) Levels of active IL-1β, IL-18, pro-caspase-1, cleaved caspase-1 (p20) and ASC in the colonic tissues were determined by western blot. Data were from 4 mice were shown. (B) CD45+ cell, (C) mast cells, macrophages, neutrophils and (D) subpopulations of DCs were detected using flow cytometry. The results (B–D) are shown as the mean ± SD of 10 mice per group. ns: no statistical significance, *P < 0.05 and **P < 0.01, compared with the group AOM + DSS + PBS. AOM + DSS + PBS: AOM/DSS-induced CAC mice and injected with PBS, AOM + DSS + F991: AOM/DSS-induced CAC mice and injected with F991. One representative experiment of two is displayed.

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