Figure 1
From: PSMA expression by microvasculature of thyroid tumors – Potential implications for PSMA theranostics
PSMA immunoreactivity in representative thyroid samples. PSMA is expressed by endothelium of thyroid tumors (B–H), but not of benign thyroid (A,C). Arrowheads indicate microvessels with red blood cells in non-neoplastic thyroid tissue. Note absence of PSMA expression by benign or neoplastic epithelium, except one case of PDTC (F). (A) Benign thyroid. (B) Follicular adenoma. (C) Interface between follicular cancer and adjacent thyroid tissue. PSMA expression is restricted to the tumor microvasculature. (D) Follicular thyroid carcinoma. (E) Papillary thyroid carcinoma, classic variant. PSMA-positive capillaries decorate papillary cores. (F) Poorly differentiated thyroid carcinoma with ectopic PSMA expression by cancer cells added by predictable immunoreactivity in tumor-associated endothelium. (G) Anaplastic thyroid carcinoma. (H) Medullary thyroid carcinoma. Immunohistochemistry, 200× (A–H).
