Figure 1
From: eIF2α signaling regulates ischemic osteonecrosis through endoplasmic reticulum stress
Salubrinal suppresses bone loss in ONFH. (a) Representative μ-CT reconstructed image of the femoral head (Bar = 1 mm). (b–e) Architectural properties in ONFH were measured by μ-CT. (b) Fractional bone volume (BV/TV). (c) Trabecular number (Tb.N). (d) Trabecular thickness (Tb.Th). (e) Trabecular spacing (Tb.Sp). (f) Bone mineral density (BMD). (g) Bone mineral content (BMC). (h–j) Representative histological images of the femoral head by H&E staining (h) 100×, Bar = 200 μm, and (j) 400×, Bar = 50 μm. Empty lacunae were indicated by the arrows. (i) Ratio of the trabecular bone area to the tissue area (B.Ar/T.Ar). (k) Percentage of empty lacunae. The asterisks (*, **, and ***) represent P < 0.05, P < 0.01, and P < 0.001, respectively (n = 12) (Sham: sham control group, ON: osteonecrosis group, ON + S: salubrinal treated osteonecrosis group).
