Figure 4
From: eIF2α signaling regulates ischemic osteonecrosis through endoplasmic reticulum stress
Salubrinal elevates blood perfusion in ONFH and protects viability of endothelial cells against ER stress. (a) Representative histological images of the femoral head by ink perfusion angiography. The vessels were indicated by the arrows (40×; Bar = 1 mm). The quantification of the vessel number (b) and vessel area percentage (c) in each field of view (200×) was conducted. (d–g) MTT assay for cell viability of HUVECs. The histogram showed relative cell viability from three independent experiments. The asterisks (*, ** and ***) represent P < 0.05, P < 0.01, and P < 0.001, respectively (S: Salubrinal, and Tm: Tunicamycin).
