Figure 3
From: Non-ketogenic combination of nutritional strategies provides robust protection against seizures
CD treatment decreases susceptibility to seizures. (A,B) Injection of pentylenetetrazol (PTZ; 50 mg/ml) i.p. promptly resulted in paroxysmal events and status epilepticus in control SD fed mice. In mice receiving KD or CD treatment, the ictus (example indicated by a black bar) was triggered significantly later (SD, n = 7; KD, n = 5, p < 0.01; CD, n = 8, p < 0.001), indicating a similar protective effect of both diets. (A,C) Corroborating this finding, the frequency of interictal events (example shown by an arrow) was found to be significantly reduced in both KD and CD fed mice compared to SD controls (all p < 0.05). Calibration bars: 10 s, 500 µV. *p < 0.05, **p < 0.01, ***p < 0.001.
