Table 9 Gravity-responsive transcripts.
From: Dynamic gene expression response to altered gravity in human T cells
Transcript | Function | Gene Ontology Molecular function | Gene Ontology Biological process | # in Fig. 13 | |
|---|---|---|---|---|---|
Parabolic flight experiment (23rd DLR PFC) | |||||
RNU5D-1 RNA, U5D Small Nuclear 1 | affiliated with the small nuclear ribonucleic acid, processing of pre-messenger RNA in the nucleus | — | — | 8 | |
SNORD63 Small Nucleolar RNA, C/D Box 63 | snoRNA | — | — | 8 | |
AC083843.1 | RNA Gene | — | — | 8 | |
OR12D3 Olfactory Receptor Family 12 Subfamily D Member 3 | G-protein-coupled receptors (GPCR), recognition and G protein-mediated transduction of extracellular signals | GO:0004888 transmembrane signaling receptor activity GO:0004930 G-protein coupled receptor activity GO:0004984 olfactory receptor activity | GO: 0007186 G-protein coupled receptor signaling pathway GO:0050907 detection of chemical stimulus involved in sensory perception GO:0050911 detection of chemical stimulus involved in sensory perception of smell | 9 | |
Suborbital rocket experiment (TEXUS-51) | |||||
GTF3C6 General Transcription Factor IIIC Subunit 6 | GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5 S RNA tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. | GO:0003677 contributes to DNA binding GO:0005515 protein binding | GO:0006351 transcription, DNA-templated GO:0006383 transcription from RNA polymerase III promoter GO:00427915 S class rRNA transcription from RNA polymerase III type 1 promoter GO:0042797 tRNA transcription from RNA polymerase III promoter | 4 | |
KLF12 Kruppel Like Factor 12 | Transcription Factor | GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0001227 transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003714 transcription corepressor activity | GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0045944 positive regulation of transcription from RNA polymerase II promoter | 4 | |
HMGB1P4 High Mobility Group Box 1 Pseudogene 4 | — | — | — | — | |
ANP32C Acidic Nuclear Phosphoprotein 32 Family Member C | tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers | — | — | 7 | |
ANP32D Acidic Nuclear Phosphoprotein 32 Family Member D | tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers | — | — | 7 | |
MOB1B MOB Kinase Activator 1B | related pathways are Signaling by GPCR and Hippo signaling pathway, related to kinase binding and kinase activator activity | GO:0005515 protein binding GO:0019209 kinase activator activity GO:0019900 kinase binding GO:0046872 metal ion binding | GO:0031952 regulation of protein autophosphorylation GO:0035329 hippo signaling GO:0042327 positive regulation of phosphorylation | 1 | |
CKS2 CDC28 Protein Kinase Regulatory Subunit 2 | CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases inhibits the activation of cyclin A/CDK2 kinase, involved in the G1/S transition of the cell cycle | GO:0003682 chromatin binding GO:0005515 protein binding GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity GO:0019901 protein kinase binding GO:0042393 histone binding | GO:0006355 regulation of transcription, DNA-templated GO:0007127 meiosis I GO:0007346 regulation of mitotic cell cycle GO:0008283 cell proliferation GO:0044772 mitotic cell cycle phase transition | 6 | |
FABP5P7 Fatty Acid Binding Protein 5 Pseudogene 7 | Pseudogene | — | — | — | |
FABP5P1 Fatty Acid Binding Protein 5 Pseudogene 1 | Pseudogene | — | — | — | |
LOC732360 | Non coding RNA | — | — | 8 | |
LOC644172 Mitogen-Activated Protein Kinase 8 Interacting Protein 1 Pseudogene | related to Wnt signaling pathway | — | — | 2 | |
KPNB1 Karyopherin Subunit Beta 1 | Nucleocytoplasmic transport, a member of the importin beta family | GO:0005515 protein binding GO:0008139 nuclear localization sequence binding GO:0008270 zinc ion binding GO:0008536 Ran GTPase binding GO:0008565 protein transporter activity | GO:0000059 protein import into nucleus, docking GO:0000060 protein import into nucleus, translocation GO:0006309 apoptotic DNA fragmentation GO:0006606 protein import into nucleus GO:0006607 NLS-bearing protein import into nucleus | 3 | |
MPHOSPH6 M-Phase Phosphoprotein 6 | involved in rRNA processing and gene expression, 3’-processing of the 7 S pre-RNA to the mature 5.8 S rRNA, might may play a role in recruiting the RNA exosome complex to pre-rRNA | GO:0003723 RNA binding GO:0005515 protein binding | GO:0000460 maturation of 5.8 S rRNA GO:0006364 rRNA processing | 5 | |
Parabolic flight (23 rd DLR PFC) and suborbital rocket (TEXUS-51) experiment | |||||
ATP6V1A/D ATPase H + transporting V1 subunit | multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles | GO:0005524 ATP binding GO:0046961 Protone-transporting ATPase activity, rotational mechanism | GO:0006810 transport GO:0008286 insulin receptor signaling pathway GO:0015991 ATP hydrolysis coupled proton transport GO:0016241 regulation of macroautophagy GO:0033572 transferrin transport | — | |
LINC00837 Lonng Intergenic Non-Protein Coding RNA 837 | Non-coding RNA class | — | — | — | |
IGHD3-3/10 Immunoglobuline heavy diversity 3 | V(D)J recombination in developing lymphocytes | — | — | — | |
