Figure 2
Genomic regions interrogated by TAm-Seq for SNV analysis. ^Specificity of TERT assays was poor due to constraints of targeting short amplicons in the repetitive TERT promoter region. Data resulting from these assays were therefore excluded from downstream analysis. Other than TERT, 90–100% of mutations reported in the above listed genes were covered by the panel. Alterations in these genes would capture 72% of alterations reported in MIBC patients. The prevalence of the mutations shown here are based upon data generated by the TCGA Research Network: http://cancergenome.nih.gov/. Green squares represent missense mutations and black squares represent truncating mutations38, 39. The number of patients (and percentage of patients) with SNVs detected in TUR and in any body fluid at any time-point are shown for each gene.
