Figure 2
From: Discovery of Novel Human Gene Regulatory Modules from Gene Co-expression and Promoter Motif Analysis
Motif target identified through motif position bias towards TSS. (a) A diagram showing a group of promoters. Within the promoters, a random/non-functional motif (grey triangle) distributes randomly along the promoters, while a functional motif (solid black triangle) distributes towards the transcription start site (TSS). The white bars represent transposon or repetitive sequence in the promoters, which are excluded from motif analysis. The arrow indicates the direction of transcription. (b) A representative distribution of a random/non-functional motif (grey line) and a functional motif (black line) with bias distribution along promoters. (c) Distribution of the NF-Y (CCAAT) motif within gene promoters from the modules regulated by this motif. Data from the first 10 modules shown in Supplementary Dataset 3 are indicated by different colors, as specified by the color key on the top left. (d) Distribution of the Sp1 motif within the gene promoters for modules regulated by the Sp1 motif. Data from first 10 modules shown in Supplementary Dataset 5 are indicated by different colors, as specified by the color key on the top left.
