Figure 5
From: Discovery of Novel Human Gene Regulatory Modules from Gene Co-expression and Promoter Motif Analysis

A gene regulatory system with different layers of regulations. The gene regulatory system consists of three layers: gene co-expression network, transcription factors network, and epigenetic regulation. Gene co-expression network capture the output of the regulatory system, i.e. the expression patterns, which are regulated by both transcription factors network and epigenetic regulation.