Figure 7
From: Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease
Levels of both SGPL1 are defective in brain tissues from R6/2 mice at early stages of the disease. Representative cropped immunoblottings and densitometric analysis of SGPL1 and SPHK1/2 isoform expression in striatal (A–C) and cortical (D,E) tissues from early manifest (6 week old) R6/2 mice and WT littermates. Values are represented as mean ± SD. N = 5 for each group of mice. **p < 0.001 (Unpaired t-test).
