Figure 5
From: Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis
(a) Identification of S. cerevisiae and C. albicans genes that rescue Trifluoperazine toxicity at high copy. Serial dilutions of S. cerevisiae cells carrying the indicated genes on a 2 micron plasmid were plated on YPD or YPD + 30 µM TFP plates and incubated for 2 days at 30 °C. (b) MIC test of TFP on C. albicans vma11 −/−(KC280) vs. VMA11 +/+ (CAF3-1). The cells were grown in YPD overnight at 37°C in the presence of TFP at the indicated concentrations. The graph indicates the mean ± S.D. of three cultures.
