Figure 7 | Scientific Reports

Figure 7

From: Evidence of selection on splicing-associated loci in human populations and relevance to disease loci mapping

Figure 7

Disease susceptibility variant rs4506565 in TCF7L2. (a) Significant association with Type 2 Diabetes. (b) rs4506565 is highly differentiated among populations and shows the highest F ST = 0.43 between AFR and ASN populations. (c) Model of exon skipping affected by rs4506565 in intronic splicing enhancer and impact of the skipped exon on protein domain region.

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