Figure 2
From: Common variants of T-cells contribute differently to phenotypic variation in sarcoidosis
Summary of polygenic scores derived from T-lymphocyte subsets and CD4/CD8 ratio by Pdiscovery thresholds for LS (384 cases and 2,086 controls) using unpruned sets. Tabulated results for score P-values and discriminatory analysis metrics are available in Supplementary Table 1. Baseline represents the percentage of explained variance obtained from the null model adjusted for gender and age. R2 is the percentage of explained variance at Pdiscovery thresholds (17 sets, starting from 5.0E-8 to 1.0); R2_CD3 represents the percentage of explained variance using CD3-associated variants; R2_CD4 represents the percentage of explained variance using CD4-associated variants; R2_CD8 represents the percentage of explained variance using CD8-associated variants; and R2_CD4/CD8 represents the percentage of explained variance using CD4/CD8-associted variants.
