Table 3 Summary of polygenic scores derived from T-cells subsets (CD4+ and CD8+) and CD4:CD8 ratio by chromosome for non-LS sarcoidosis (664 cases and 2,086 controls) using unpruned sets.
From: Common variants of T-cells contribute differently to phenotypic variation in sarcoidosis
CHR | CD4+ | CD8+ | CD4/CD8 ratio | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nagelkerke R2 (%) | % of explained variance | C-statistic | SCORE P-value | Nagelkerke R2 (%) | % of explained variance | C-statistic | SCORE P-value | Nagelkerke R2 (%) | % of explained variance | C-statistic | SCORE P-value | |
Baseline | 17.40% | 0.00% | 0.73 | 1.23E-73 | 17.40% | 0.00% | 0.73 | 1.23E-73 | 17.40% | 0.00% | 0.73 | 1.23E-73 |
1 | 17.10% | 0.30% | 0.74 | 1.17E-01 | 17.05% | 0.35% | 0.73 | 2.14E-01 | 16.97% | 0.43% | 0.73 | 9.48E-01 |
2 | 17.03% | 0.37% | 0.74 | 2.93E-01 | 17.29% | 0.11% | 0.74 | 1.38E-02 | 17.11% | 0.29% | 0.74 | 1.03E-01 |
3 | 17.04% | 0.36% | 0.73 | 2.49E-01 | 16.99% | 0.42% | 0.73 | 6.10E-01 | 16.98% | 0.43% | 0.73 | 8.30E-01 |
4 | 17.04% | 0.36% | 0.74 | 2.51E-01 | 17.06% | 0.35% | 0.74 | 2.08E-01 | 16.99% | 0.42% | 0.73 | 6.28E-01 |
5 | 16.97% | 0.43% | 0.73 | 9.23E-01 | 17.17% | 0.24% | 0.74 | 5.55E-02 | 17.15% | 0.26% | 0.74 | 7.10E-02 |
6 | 17.81% | 0.41% | 0.74 | 6.16E-05 | 16.98% | 0.43% | 0.73 | 8.46E-01 | 17.10% | 0.30% | 0.73 | 1.16E-01 |
7 | 16.98% | 0.43% | 0.73 | 8.57E-01 | 17.07% | 0.34% | 0.73 | 1.79E-01 | 17.00% | 0.40% | 0.73 | 4.49E-01 |
8 | 17.01% | 0.39% | 0.73 | 3.83E-01 | 16.97% | 0.43% | 0.73 | 9.93E-01 | 16.99% | 0.41% | 0.73 | 5.76E-01 |
9 | 17.03% | 0.38% | 0.74 | 3.23E-01 | 16.98% | 0.42% | 0.73 | 6.46E-01 | 16.97% | 0.43% | 0.73 | 8.73E-01 |
10 | 16.99% | 0.42% | 0.73 | 6.32E-01 | 17.30% | 0.11% | 0.74 | 1.35E-02 | 17.29% | 0.12% | 0.74 | 1.47E-02 |
11 | 16.98% | 0.43% | 0.73 | 8.10E-01 | 16.99% | 0.41% | 0.73 | 5.38E-01 | 17.03% | 0.37% | 0.73 | 2.94E-01 |
12 | 17.01% | 0.40% | 0.74 | 4.42E-01 | 16.99% | 0.41% | 0.73 | 5.31E-01 | 17.07% | 0.34% | 0.74 | 1.80E-01 |
13 | 16.99% | 0.42% | 0.73 | 6.11E-01 | 17.08% | 0.32% | 0.74 | 1.52E-01 | 17.11% | 0.29% | 0.74 | 1.03E-01 |
14 | 17.03% | 0.38% | 0.74 | 3.06E-01 | 17.04% | 0.36% | 0.74 | 2.56E-01 | 16.98% | 0.43% | 0.73 | 8.01E-01 |
15 | 17.05% | 0.36% | 0.73 | 2.46E-01 | 17.00% | 0.41% | 0.74 | 5.04E-01 | 17.17% | 0.24% | 0.74 | 5.59E-02 |
16 | 17.08% | 0.32% | 0.74 | 1.51E-01 | 17.00% | 0.41% | 0.74 | 5.20E-01 | 17.23% | 0.18% | 0.74 | 2.87E-02 |
17 | 16.99% | 0.42% | 0.73 | 6.02E-01 | 17.06% | 0.35% | 0.74 | 2.05E-01 | 17.00% | 0.41% | 0.74 | 4.85E-01 |
18 | 17.04% | 0.36% | 0.74 | 2.63E-01 | 17.07% | 0.33% | 0.74 | 1.76E-01 | 16.98% | 0.43% | 0.73 | 7.85E-01 |
19 | 16.98% | 0.43% | 0.73 | 7.95E-01 | 16.97% | 0.43% | 0.73 | 9.93E-01 | 16.97% | 0.43% | 0.73 | 9.82E-01 |
20 | 16.98% | 0.42% | 0.74 | 6.96E-01 | 16.97% | 0.43% | 0.73 | 9.85E-01 | 16.99% | 0.41% | 0.73 | 5.29E-01 |
21 | 17.00% | 0.40% | 0.73 | 4.55E-01 | 17.03% | 0.37% | 0.74 | 2.96E-01 | 17.00% | 0.40% | 0.74 | 4.43E-01 |
22 | 16.99% | 0.42% | 0.73 | 6.25E-01 | 17.00% | 0.40% | 0.73 | 4.70E-01 | 17.12% | 0.29% | 0.74 | 9.97E-02 |
