Figure 5
From: Taxanes and platinum derivatives impair Schwann cells via distinct mechanisms
Changes in mitochondrial activity in Schwann cells after treatment with paclitaxel, cisplatin or oxaliplatin. (a) Fluorescence micrographs of Schwann cells labeled with the MitoTracker probe (red) and DAPI (blue). Schwann cells were treated with vehicle (0.1% DMSO), paclitaxel (0.01 μM), cisplatin (1 μM) or oxaliplatin (3 μM) for 48 h. Scale bar: 50 μm (10 μm in enlarged images) in the vehicle-treated group. (b) Number of mitochondria-labeled cells per 100 DAPI-positive cells. The intensity and number of fluorescently labeled mitochondria were reduced after treatment with either cisplatin or oxaliplatin, but not after treatment with paclitaxel. Each column represents the mean ± S.E.M. n = 12. *p < 0.05 and **p < 0.01 vs. the vehicle-treated group.
