Figure 7 | Scientific Reports

Figure 7

From: An integrated strategy by using target tissue metabolomics biomarkers as pharmacodynamic surrogate indices to screen antipyretic components of Qingkaikling injection

Figure 7

The metabolic pathway of baicalin-related targets relate to verified biomarkers and fever-related molecules. (a) The metabolic pathway of baicalin-related target CASP3 relate to fever-related molecule PGF2α (Yellow indicates CASP3, green indicates IMP and N6-(1,2-dicarboxyethyl)-AMP and red indicates PGF2α); (b) Metabolic pathway of baicalin-related target CASP3 relate to fever-related molecule NO (Yellow indicates CASP3, green indicates IMP and N6-(1,2-dicarboxyethyl)-AMP and blue indicates fever-related molecule NO); (c) The metabolic pathway of baicalin-related target HIF-1α relate to fever-related small molecule cAMP (Yellow indicates HIF-1α, green indicates N6-(1,2-dicarboxyethyl)-AMP and azure indicates cAMP); (d) Metabolic pathway of baicalin-related target HIF-1α to fever-related molecule PGE2, PGF2α (Yellow indicates HIF-1α, green indicates IMP and N6-(1,2-dicarboxyethyl)-AMP and red indicates PGE2, PGF2α).

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