Table 2 Metabolites selected as biomarkers characterized in hypothalamus profiles and their change trends.
No. | Compounds | t R (min) | m/z | VIP | Trend in MGa | Trend in TGb |
|---|---|---|---|---|---|---|
Positive ion mode | ||||||
1 | Adenosine monophosphate (AMP) | 6.99 | 348.0700 | 6.4 | ↑*** | ↓* |
2 | ADP-D-ribose | 10.26 | 560.0785 | 2.75 | ↑*** | ↓*** |
3 | Guanosine monophosphate (GMP) | 10.88 | 364.0648 | 3.49 | ↑*** | ↓*** |
4 | Adenosine | 11.52 | 268.1042 | 1.83 | ↑** | ↓ |
5 | Inosinic acid (IMP) | 12.22 | 349.0539 | 3.17 | ↑*** | ↓*** |
6 | N6-(1,2-dicarboxyethyl)-AMP | 17.97 | 464.0794 | 2.58 | ↑*** | ↓*** |
Negative ion mode | ||||||
1 | L-Aspartic acid | 2.91 | 132.0302 | 1.42 | ↑* | ↓** |
2 | 5’-CMP | 3.47 | 322.0441 | 1.21 | ↑** | ↓** |
3 | D-Glucuronic acid | 4.27 | 175.0248 | 4.03 | ↑*** | ↓** |
4 | Adenosine monophosphate (AMP) | 7.09 | 346.0552 | 10.3 | ↑*** | ↓*** |
5 | Uridine | 9.27 | 243.0620 | 2.75 | ↓** | ↑* |
6 | Oxidised glutathione | 9.61 | 611.1441 | 5.32 | ↑*** | ↓*** |
7 | N-acetylaspartylglutamic acid | 10.80 | 303.0831 | 2.38 | ↑* | ↓* |
8 | Guanosine monophosphate (GMP) | 10.97 | 362.0502 | 4.64 | ↑*** | ↓*** |
9 | ADP | 11.23 | 426.0220 | 1.75 | ↑* | ↓*** |
10 | Inosinic acid (IMP) | 12.33 | 347.0388 | 7.34 | ↑** | ↓*** |
11 | UDP-D-galactose | 17.01 | 565.0474 | 3.27 | ↑** | ↓*** |
12 | N6-(1,2-dicarboxyethyl)-AMP | 18.10 | 462.0667 | 4.97 | ↑*** | ↓*** |
