Figure 7 | Scientific Reports

Figure 7

From: Metformin ameliorates the Phenotype Transition of Peritoneal Mesothelial Cells and Peritoneal Fibrosis via a modulation of Oxidative Stress

Figure 7

Differential Effect of Compound C on Metformin- and AICAR-induced Amelioration of EMT. Compound C, AMPK inhibitor, dose not reverse the protective effect of metformin on TGF-β1-induced EMT at 12 hours (A), but partially inhibits the effect of metformin at 48 hours of TGF-β1 stimulation (B). Effect of AICAR on TGF-β1-induced EMT is blocked by compound C at 12 (A) and 48 hours (B). N = 4. *p < 0.05 vs. others, #p < 0.05 vs. TGF-β1, †p < 0.05 vs. TGF-β1+ AICAR or metformin.

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