Figure 5
From: The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling
Angiocrine activity of APC-secreted LEP (a) LEPR silencing inhibited the proliferative effect of hypoxic APC-CM on HUVECs. *p < 0.05 and ***p < 0.001 vs. EGM2 # p < 0.05 vs. scramble. (b) LEPR silencing abolished the promotion of HUVEC network formation by hypoxic APC-CM. *p < 0.05 vs. EGM2 # p < 0.05 vs. scramble. (c) Blockade of LEP signalling increases the vascular resistance of HUVEC monolayers exposed to hypoxic APC-CM. ***p < 0.001 vs. control.
