Figure 7
From: The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling
Schematic representation of LEP signalling activated by hypoxia in human adventitial pericytes. An autocrine loop is activated through induced expression and secretion of LEP which binds to the LEPR on pericyte surface. The paracrine loop is mediated by secreted LEP inducing functional responses in other cells, like endothelial cells. The autocrine and paracrine loops result in functional adaptations to hypoxia. Arrows indicate enhanced or reduced function. Hypoxia activates miR-210, which in other cell types activates LEP production and PTP1B-mediated dephosphorylation of pJAK2. However, in human APCs, miR-210 is not responsible for modification of LEP secretion or signalling.
