Figure 2
Shared expression changes with age and shared reversals. (a) The number of consistent expression changes in development and aging. Interestingly, there is a trend toward 1.7% more consistently up-regulated genes during development, and 12.3% more consistently down-regulated genes during aging. This was also in line with 16/19 datasets harboring more up-regulated significant genes during development, and 10/12 datasets harboring more down-regulated significant genes during aging (Figure S2). (b) The proportion of different trends in age-related expression change in each dataset and among the genes showing consistent change across datasets. No effect size or significance cutoff was used. Up-down: up-regulation in development and down-regulation in aging; Down-up: down-regulation in development and up-regulation in aging; Monotonic increase: up-regulation in development and up-regulation in aging; Monotonic decrease: down-regulation in development and down-regulation in aging. (c) Average expression trajectories of consistent reversal gene clusters, plotted against individual age. The x-axis shows the age of samples on the fourth root scale and the y-axis shows the scaled mean expression level for each cluster. The spline curves indicate the mean expression change with age for each dataset and brain region.
