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Figure 2

From: Minimal hepatic encephalopathy is associated with expansion and activation of CD4+CD28−, Th22 and Tfh and B lymphocytes

Figure 2

MHE is associated with expansion of autoreactive CD4+CD28− T lymphocytes and induction of the early activation marker CD69 in CD4+ T lymphocytes in peripheral blood. (A) Percentage of total lymphocytes that are CD4+ T lymphocytes. (B) Percentage of CD4+ T lymphocytes that are naive or memory. (C) Percentage of CD4+ T lymphocytes that are autoreactive (CD4+CD28−) or not autoreactive (CD4+CD28+). (D–F) show that percentage of total CD4+ T lymphocytes (D), naive or memory CD4+ T lymphocytes (E), and autoreactive or not autoreactive CD4+ T lymphocytes (F) that express CD69. Values are the mean ± SEM of the following number of individuals: CONTROL n = 23; without MHE (NMHE) n = 30 and with MHE (MHE) n = 28. Values significantly different from controls are indicated by asterisks*. Values significantly different in patients with MHE compared to NMHE are indicated by α. (*/α p < 0.05; **p < 0.01).

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