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Figure 2

From: Absence of Tissue Inhibitor of Metalloproteinase-4 (TIMP4) ameliorates high fat diet-induced obesity in mice due to defective lipid absorption

Figure 2

Timp4 −/− mice exhibit increased food intake but reduced body fat percentage. Weekly food intake (A), rate of weekly body weight gain (Bi) and percent weight gain (Bii) in WT and Timp4 −/− mice following chow or high fat diet (HFD). (C) Dorsal and ventral view, and macroscopic images of epididymal fat pads from high fat-fed WT and Timp4 −/− mice. (D–F) Epidydimal fat, retroperitoneal fat and inguinal fat as percentage of body weight in indicated groups. (G–H) Whole body fat content (absolute, Gi; as percentage of body weight, Gii), and lean body mass (absolute, Hi; and as percentage of body weight, Hii) assessed by Echo-MRI body mass composition analysis. Significance between the chow-fed and HFD-fed groups within the genotypes are not shown in the figure. Averaged data are presented as mean ± S.E.M and analyzed by ANOVA. *p < 0.05 for the indicated groups.

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