Figure 4 | Scientific Reports

Figure 4

From: Absence of Tissue Inhibitor of Metalloproteinase-4 (TIMP4) ameliorates high fat diet-induced obesity in mice due to defective lipid absorption

Figure 4

Timp4 gene deletion protects mice from HFD-induced hepatic steatosis. H and E staining (A) and Oil Red-O staining (B) of fixed liver after 12 -weeks of chow on high fat diet (HFD) in the indicated genotypes. Representative picture of livers WT-HFD and Timp4 −/−HFD mice (C). Liver TG content (D) and hepatic cholesterol content (E) in indicated groups. (F) mRNA expression of Scd1 (i) and Pparα (ii) in the liver. (G) Skeletal muscle TG content (i) and fat deposition as indicated by Oil Red-O staining (ii) (400X). Averaged data are presented as mean ± S.E.M and analyzed by ANOVA. *Indicates significance (p < 0.05).

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