Figure 8 | Scientific Reports

Figure 8

From: Absence of Tissue Inhibitor of Metalloproteinase-4 (TIMP4) ameliorates high fat diet-induced obesity in mice due to defective lipid absorption

Figure 8

Timp4-deficiency results in defective lipid digestion and absorption. Fecal triglyceride (TG) content (Ai) in chow- or HFD-fed WT and Timp4 −/− mice. Fecal lipid analysis by thin layer chromatography in chow-fed (Aii) and HFD-fed (iii) WT and Timp4 −/− mice. (B) Immunostaining for CD36 in small intestine (proximal region) of chow-fed and HFD-fed WT and Timp4 −/− mice. Western blot (C) and mRNA (D) levels for CD36 in enterocyte fraction of chow-fed and HFD-fed WT and Timp4 −/− mice (collected from the proximal small intestine). (E) Triglyceride levels in enterocytes collected from the proximal small intestine. Averaged data are presented as mean ± S.E.M and analyzed by ANOVA. * indicates significance (p < 0.05).

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