Figure 4
From: Pattern of retinal morphological and functional decay in a light-inducible, rhodopsin mutant mouse
Spatial and temporal progression of phenotype. Correlation of ERG decay and morphological impairment of the central retina of Tvrm4 mice exposed to 1 minute, 12,000 lux conditioning light and examined after 2, 7, and 14 days. (A) Upper traces: example of scotopic ERG. Bottom traces: photopic ERG. Immunofluorescence staining insets show the progressive loss of rhodopsin immunoreactivity and disappearance of cones from the central retina in vertical sections (green: rhodopsin staining; red: cone-arrestin). (B and C) scotopic b-wave and a- wave amplitudes as a function of flash intensity in control mice and in Tvrm4 mice exposed as above. (D) photopic b-wave amplitudes. Note that before phenotype induction (pre-illumination condition, Ctr) ERG traces and retinal morphology of Tvrm4 are normal. Data collected from n = 6 animals for each experimental condition. Each point represents the mean ± SE.
