Figure 3

Inflammatory cytokine protein profiles in endometriosis patients and compared to normal fertile controls. Protein expression using multiplexing reveals higher GM-CSF and IL-10 in eutopic endometrium from patients compared to normal endometrium from fertile healthy controls (Panels A,B). Interleukin-6 was significantly upregulated in matched eutopic compared to ectopic lesions from patients (Panel C). Similarly, Interleukin-8 was upregulated in ectopic endometrium compared to matched eutopic endometrium from patients as well as in normal endometrium from healthy fertile controls (Panel D). Tumor necrosis factor alpha was higher in normal endometrium from healthy fertile controls compared to ectopic endometrium from endometriosis patients (Panel F). Expression data illustrated as mean ± SEM. *P < 0.05. Sample groups consisted of n = 22 human eutopic endometrium, n = 22 human ectopic endometriotic lesions, and n = 16 normal control endometrium.