Figure 8
From: A balancing act: RNA binding protein HuR/TTP axis in endometriosis patients
HuR and TTP is immunolocalized throughout the endometrial microenvironment in eutopic and ectopic endometrium from a mouse model of endometriosis. HuR localization patterns were examined in eutopic (Panels A,B) and ectopic (Panels C,D) endometrium. HuR immunostaining was primarily found in glandular epithelium (blue arrows; brown staining prominent in panels A), and endometrial stroma (red arrows, Panels A,C) from both eutopic and ectopic endometrium TTP was localized primarily in glandular epithelium (blue arrows; Panel A), endometrial epithelium and luminal epithelium (green arrows; prominent staining in Panel E compared to isotype negative in Panel F) in eutopic endometrium. High levels of TTP immunolocalization was noted in endometrial stroma in ectopic lesions (Panel G compared to isotype negative Panel H). Images are representative of 5 slides from 6 mice from 2 experiments (n = 3 day 7, n = 3 day 17). Panels A,B original magnification, 100X, scale bar: 75 µm. Panels C,D,G,H original magnification, scale bar: 300 µm 200X, Panels E,F original magnification, 40X, scale bar: 300 µm.
