Figure 5
From: Anti-AMPA GluA3 antibodies in Frontotemporal dementia: a new molecular target
Neurobiological effect of GluA3 antibodies in neurons differentiated from human iPSCs. (A) WB analysis from homogenates and triton-insoluble postsynaptic fractions (TIF) of neurons differentiated from human iPSC and incubated for 24 hours with CSF with (CSF+) or without (CSF−) anti-GluA3 antibodies (dilution 1:100). (B,C) The histogram shows the quantification of the expression levels of GluA3, GluA1 and PSD-95 in homogenate (B) and TIF (C), normalized on tubulin and expressed as % of CSF−. N = 5 ***p < 0.001, unpaired Student’s t-test.
