Figure 1 | Scientific Reports

Figure 1

From: Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats

Figure 1

RV pacing-induced decrease in LV hemodynamic performance is related to both dyssynchrony and impaired AV coupling. Analysis of rats implanted with an atrial (A) bipolar electrode and a right ventricular (RV) bipolar electrode for sequential A + RV pacing. (A) ECG recording (lead I) during: Left; override A pacing. Mid; override A + RV pacing (AV-interval = 50 ms) or RV-only pacing. Right; override A + RV pacing (AV-interval = 35 ms) or RV-only pacing. Vertical bars at the bottom indicate A pacing; arrows indicate RV pacing. Note fusion beats with an AV interval of 50 ms and absence of fusion beats when the AV interval was reduced to 35 ms. (B) PV-loop recordings during A pacing, A + RV pacing (using the maximal AV-interval that did not induce fusion beats) and RV-only pacing. Comparison of A vs. A + RV pacing shows the effects of LV dyssynchrony, while RV-only pacing also induces preload reduction due to impaired AV coupling.

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