Figure 5 | Scientific Reports

Figure 5

From: Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats

Figure 5

RV tachypacing induces global activation of CAMKII. Biochemical analysis of CAMKII in rats subjected to either RV tachypacing or BiV tachypacing at a CL of 100 ms for 72 hours. La = lateral wall, Sp = septum. (A) An immunoblot demonstrating phospho-CAMKII (p-CAMKII) levels and GAPDH (loading control). Cropped blots are shown. Uncropped blots are presented in Supplementary Fig. 5S. (B) Bar graph summarizing the p-CAMKII densitometry results of each pacing mode. Note the marked increase of p-CAMKII in both septum and lateral wall of rats exposed to RV tachypacing. In comparison with the RV-paced rats, BiV-paced rats demonstrated reduced p-CAMKII levels mainly in the septum. (C) Immunoblot for total CAMKII. Cropped blots are shown. Uncropped blots are presented in Supplementary Fig. 5S. (D) Bar graph summarizing the CAMKII densitometry results at each pacing mode.

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