Table 1 PV loop analysis of rats implanted with RA and RV pacing electrodes.

From: Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats

Parameter

A pacing

A + RV pacing

RV pacing

P value

 Pacing CL (ms)

150

150

150

 Pmean (mm Hg)

59.84 ± 2

59.86 ± 1.8

51.4 ± 2.3#,^

<0.001

 Pdev (mm Hg)

118.9 ± 4.1

114.2 ± 4.3*

105.6 ± 4#,^

<0.001

 ESP (mmHg)

104.3 ± 8

109.4 ± 4.5

100.8 ± 4.5#,^

0.008

 EDP (mmHg)

5.4 ± 0.5

5.9 ± 0.5

5.7 ± 0.8

NS

 ESV (μL)

51.1 ± 11.4

81.8 ± 9.2*

59.1 ± 10.1#

<0.001

 EDV (μL)

283.4 ± 18.1

286.9 ± 16.4

233.5 ± 22.1#,^

<0.001

 SV (mL)

232.4 ± 8.5

205.1 ± 9.6*

174.4 ± 13.8#,^

<0.001

 Ea (mm Hg/μL)

0.45 ± 0.03

0.54 ± 0.02*

0.59 ± 0.04^

0.004

Systolic indices

 EF (%)

83.3 ± 3.2

72.0 ± 2.3*

75.9 ± 2.9^

<0.001

 SW (mm Hg*μL)

21104 ± 1074

17061 ± 1810*

13356 ± 1767#,^

<0.001

 dP/dt max (mm Hgs−1)

8737.9 ± 406

7048 ± 415*

6639.0 ± 433^

<0.001

Diastolic indices

 dP/dt min (mm Hgs−1)

−8076 ± 310.4

−6407.6 ± 402.1*

−6837.9 ± 359.5^

<0.001

 Tau (ms)

9.87 ± 0.32

12.14 ± 0.46*

10.77 ± 0.38#,^

<0.001

  1. Repeated P-V loop measurements in rats under atrial (A), sequential atrial and RV (A + RV) and RV only pacing modes (n = 8 for all). Statistical analysis was performed using non-parametric repeated measure ANOVA (Friedman test). Symbols indicate significant difference in post-test analysis; *RA + RV vs. RA (ventricular dyssynchrony component), #RV vs. RA + RV (AV physiology component), ^RV vs. RA (combined ventricular dyssynchrony and AV physiology components). Pmean = mean pressure; Pdev = developed pressure; ESP-end systolic pressure; EDP-end diastolic pressure; ESV = end systolic volume; EDV = end diastolic volume; SV = stroke volume; Ea = arterial elastance; EF = ejection fraction SW = stroke work.