Table 2 PV loop analysis of rats implanted with RV and LV pacing electrodes.

From: Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats

Parameter

RV pacing

LV pacing

BiV pacing

P value

 Pacing CL (ms)

150

150

150

 Pmean (mm Hg)

45.1 ± 1.8

46.3 ± 1.9

49.3 ± 1.3#,^

0.005

 Pdev (mm Hg)

93.3 ± 2.7

95.5 ± 2.4

99.6 ± 2.0#,^

0.002

 ESP (mmHg)

86.7 ± 4.6

81.7 ± 6.3

84.6 ± 6.1

NS

 EDP (mmHg)

8.3 ± 1

7.4 ± 1.1

8.5 ± 1.1

NS

 ESV (μL)

76.1 ± 24.3

85.1 ± 23.8

82.7 ± 22.1

NS

 EDV (μL)

288.9 ± 34.6

401.5 ± 17.8*

438.5 ± 29.1#

<0.001

 SV (mL)

212.6 ± 22.4

316.4 ± 22.5*

355.7 ± 35.7#

<0.001

 Ea (mm Hg/μL)

0.46 ± 0.07

0.27 ± 0.03*

0.26 ± 0.03#

<0.001

Systolic indices

 EF (%)

75.3 ± 4.8

79.2 ± 4.8

80.7 ± 4.8

NS (0.07)

 SW (mm Hg*μL)

16084 ± 2008

24912 ± 2187*

27393 ± 2721#

<0.001

 dP/dt max (mm Hgs−1)

5747.1 ± 389.7

6433.6 ± 271.6*

6824.3 ± 345.9#,^

<0.001

Diastolic indices

 dP/dt min (mm Hgs−1)

−5394.6 ± 305.2

−5476.1 ± 275.2

−5777.6 ± 223.6

NS

 Tau (ms)

10.2 ± 0.46

10.41 ± 0.47

10.38 ± 0.55

NS

  1. Repeated P-V loop measurements in rats under RV, LV and BiV pacing modes (n = 8 for all). Statistical analysis was done using repeated measure one way ANOVA. Symbols indicate significant difference in post-test analysis; *LV vs. RV, #BiV vs. RV, ^BiV vs. LV. Pmean = mean pressure; Pdev = developed pressure; ESP-end systolic pressure; EDP-end diastolic pressure; ESV = end systolic volume; EDV = end diastolic volume; SV = stroke volume; Ea = arterial elastance; EF = ejection fraction SW = stroke work.