Table 1 Transcription factor contributions to gene expression and the number of regulated genes.

From: Associating transcription factors and conserved RNA structures with gene regulation in the human brain

TF

\({\bar{{\boldsymbol{r}}}}_{{\boldsymbol{\max }}}\)

Tel

MET

Cx

Cb

BF

T sel

\({{\boldsymbol{n}}}_{{\boldsymbol{robust}}{\boldsymbol{:}}{{\boldsymbol{T}}}_{{\boldsymbol{sel}}}}\)

MAX

2

149.86

48.49

110.93

61.87

31.22

Tel

180

TAF1

5

64.96

30.47

45.91

42.36

10.57

Tel

101

YY1

9

59.05

23.72

59.57

19.39

13.65

Tel

90

POLR2A

11

88.05

23.94

76.97

52.09

12.82

Tel

252

CEBPB

12

30.99

86.87

25.25

36.43

12.23

MET

64

JUND

14

35.75

17.39

41.50

21.93

13.47

Tel

34

NFYB

14

30.53

12.19

24.15

21.35

16.73

Tel

52

REST

14

38.72

47.50

21.51

25.24

9.5

MET

39

GABPA

15

49.29

26.25

41.12

52.55

18.06

Tel

101

TCF12

17

24.99

20.16

19.65

18.06

3.33

Tel

25

SP1

18

27.89

11.52

17.05

15.68

6.77

Tel

54

EZH2

81

3.42

19.02

2.83

19.62

1.47

MET

11

NR3C1

40

32.39

26.20

33.00

22.60

3.55

Cx

20

SRF

95

2.24

0.88

0.94

1.19

10.57

BF

5

  1. Transcription factors (TF) with the strongest contribution to gene expression (ranked ≥20 in all regions) are given in the upper part and TFs with localized contributions are shown in the lower part of the table. \({\bar{r}}_{max}\) is the maximum (worst) rank in any region for the TF. Tel (telencephalon), MET (metencephalon), Cx (cerebral cortex), Cb (cerebellum) and BF (basal forebrain) show the contribution to gene expression of the TF in the specified region. These values are averages over five runs of the analysis initialized with different seed for the random number generator. T sel indicates the region with the highest contribution to gene expression at depth 2 for brain-wide active TFs and a selected region with localized contributions for locally active TFS. \({n}_{robust:{T}_{sel}}\) refers to the number of TF-gene interactions that were consistently predicted in these five runs for the correspoding region.
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