Figure 7 | Scientific Reports

Figure 7

From: Solute carriers affect Anopheles stephensi survival and Plasmodium berghei infection in the salivary glands

Figure 7

Proposed model for prestinA and NDAE1 physiological functions and impact on SG cell and Plasmodium berghei infection. PrestinA is expressed at apical membrane of cells, mediates the uptake of sulfate and excretes bicarbonate which is produced by carbonic anhydrase or supplied by NDAE1. Disruption of prestinA alters the biosynthesis of chondroitin sulfate which interferes with Plasmodium adhesion. A reduction of both prestinA and NDAE1 changes cell pH, affecting Plasmodium and mosquito survival.

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