Figure 3
Domain representation of positively selected genes. Sites showing evidence of positive selection are mapped onto the domain representation of the proteins and colour-coded as follows: orange, positively selected sites on the mammalian branch; green, positively selected sites on the sauropsidan branch; black, positively selected sites in the mammalian phylogeny. Selected sites in the human, chimpanzee or gorilla lineages are highlighted in cyan, yellow and violet, respectively. Positions refer to human sequences (Supplementary Table S1). Domain names and functions are reported in the legend. Black stars indicate missense mutations associated to ASD, ID, SCZ, and other neurodevelopmental disorders33, 79, 82, 120,121,122,123.
